Hou et al (2005) analyzed the autonomic results of modafinil in humans. They observed that modafinil has an effect on the locus coeruleus, which mediates pupil diameter and arousal, but it doesn't influence other autonomic features, which can be controlled by noreadrenergic Manage centers (A1 – A5) Found beyond the locus coeruleus.cyclophosphamid
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